[Ssb_members] Fwd: Applied Mathematics Colloquium: Dr. Eric Cytrynbaum, Wed Nov 06

[Navaira Sherwani]

Hi all,

PFA

Best,
Navaira

---------- Forwarded message ---------
From: Mark Alber <malber at ucr.edu>
Date: Mon, Nov 4, 2024 at 3:54 PM
Subject: Applied Mathematics Colloquium: Dr. Eric Cytrynbaum, Wed Nov 06
To: Ke Zhang <kzhan153 at ucr.edu>, Navaira Sherwani <nsher012 at ucr.edu>, Ruoxi
Zhao <rzhao065 at ucr.edu>, Xin Xiang <xxian002 at ucr.edu>, Rose Johnson-Leiva <
rjohn088 at ucr.edu>, Vladimir López <vlope166 at ucr.edu>, Rim Hammoud <
rhamm009 at ucr.edu>, Seth Berman <sberm026 at ucr.edu>, Qiang Kang <
qkang003 at ucr.edu>, Ethan Nowaski <enowa001 at ucr.edu>, Taylor Fisher <
gfish007 at ucr.edu>, Vas Shik <vshik001 at ucr.edu>, Kimberly Alexander <
kalex026 at ucr.edu>, Emerald Win <ewin002 at ucr.edu>, Khoi Vo <kvo020 at ucr.edu>



Dear All,

Please join us for the Mathematics Colloquium/ICQMB Lecture this Wednesday.

Prof. Eric Cytrynbaum
Department of Mathematics
University of British Columbia
Canada

*Time: *Wed. Nov. 06, 2pm-3pm.
*Location: *Skye Hall 361

*Title*: Mathematical models of spatiotemporal organization in
multicellular organisms

The Abstract of the talk is provided below.

We look forward to seeing you on Wednesday.

Best regards,

Jia Gou and Mark Alber
____________________________________________________________________________________________________________________


*Mathematics Colloquium and ICQMB Lecture*



Eric Cytrynbaum

Department of Mathematics

University of British Columbia

Canada



*Time: *Wed. Nov. 06, 2pm-3pm.

*Location: *Skye Hall 361



*Title*: Mathematical models of spatiotemporal organization in
multicellular organisms

*Abstract*: In this talk, I’ll discuss two recent lines of research in my
group, related by the common element of being a multiscale problem of
spatial organization.

(1) For over a century, the development and replacement of reptile teeth
has been of interest in comparative anatomy and evolutionary biology due to
the prevalence of teeth in the fossil record and, more recently, for
understanding spatiotemporal patterning in developmental biology as well as
the fundamentals of tooth replacement for a clinical context. In
collaboration with the Richman Lab (UBC Dentistry), we are using the
Leopard Gecko as a model organism to understand the mechanisms underlying
the regular and long-lasting spatiotemporal patterns of tooth replacement
seen in many polyphyodonts. I will describe the data and our implementation
and analysis of several mechanisms that have been proposed in the past to
explain the observations. Finding shortcomings in these models, we propose
a new model, the Phase Inhibition Model, a coupled phase oscillator model,
which does better at explaining the data.

(2) Many externally bilaterally symmetric animals, including both
vertebrates and invertebrates, have an internal left-right asymmetry that
is established during embryo development. This asymmetry can be critical
for proper organ function (e.g. the mammalian heart). In C. elegans,
left-right asymmetry (chirality) arises during cell division at the
four-cell stage and eventually manifests in a consistent handedness in the
twisting of intestine and gonad in the adult. In collaboration with the
Sugioka Lab (UBC Zoology), we are developing models to explain the onset of
chirality. Chirality appears intracellularly during cell division in the
form of chiral flow of the actomyosin cortex. We hypothesize that this flow
induces friction forces between neighboring cells mediated by adhesions.
The model takes the form of force balance differential equations and does
well in comparison with quantitative data extracted from live-cell and in
vitro imaging.

______________________________________________________________________________________________________________________________________________


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