[IIGB_All] Dae-Jin Yun Seminar July 11th

[Meng Chen]

Dear All,

Prof. Dae-Jin Yun from Konkuk University (Korea) will visit UCR and give a special seminar on cold-induced chromatin dynamics in Arabidopsis.

Title: Cold stress induced dynamic chromatin accessibility in Arabidopsis 

Time: July 11th, 12-1PM
Location: Genomic Auditorium

Synopsis:
Plants exposed to various environmental stresses, including cold temperatures,
undergo differential gene expression and activate stress response pathways by various
molecular mechanisms, including chromatin remodeling. Here, we used genome-wide
chromatin accessibility studies to investigate the dynamic changes in chromosomes in
Arabidopsis. We show the heterochromatin structure was lost in the nucleus upon cold
exposure. There was a gain in chromatin accessibility throughout the genome, and 
this was associated with histone reorganization in response to cold stress. In addition,
we observed differential gene expression that did not correspond with a gain in
chromatin accessibility upon cold stress. The differential gene expression was
mediated by positional CBFs/DREB1 (C-repeat Binding Factors/Dehydration-
Responsive Element-Binding) transcription factor recruitment. Binding of CBFs on
H2A.X.5 promoter led to its upregulation upon cold exposure. In contrast, the binding of
CBFs to H2A.W.12 enhancer led to its downregulation. Therefore, in response to
increased chromatin accessibility under cold stress, transcription factor CBFs play a
critical role in regulating gene expression depending on its binding locations in the
Arabidopsis genome.

Best,

Meng

-- 
Meng Chen
Professor of Cell Biology
Department of Botany & Plant Sciences
University of California, Riverside 
Website: http://www.plasticgenome.org/

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