<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Helvetica;
panose-1:0 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Cambria;
panose-1:2 4 5 3 5 4 6 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.msonormal0, li.msonormal0, div.msonormal0
{mso-style-name:msonormal;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
span.apple-converted-space
{mso-style-name:apple-converted-space;}
span.xapple-converted-space
{mso-style-name:xapple-converted-space;}
span.EmailStyle20
{mso-style-type:personal;
font-family:"Calibri",sans-serif;
color:windowtext;}
span.EmailStyle21
{mso-style-type:personal;
font-family:"Calibri",sans-serif;
color:windowtext;}
span.EmailStyle22
{mso-style-type:personal;
font-family:"Calibri",sans-serif;
color:windowtext;}
span.EmailStyle23
{mso-style-type:personal;
font-family:"Calibri",sans-serif;
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="#0563C1" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:red">~Reminder~</span></i></b></p>
<p class="MsoNormal"> </p>
<p class="MsoNormal"> </p>
<p class="MsoNormal"> </p>
<p class="MsoNormal" align="center" style="text-align:center"><b><i><span style="font-size:20.0pt;font-family:"Cambria",serif">Please join us for the<span class="apple-converted-space"> </span>BPSC 250 Series Winter 2022</span></i></b></p>
<div>
<p class="MsoNormal" style="background:white"><span style="color:black"> </span></p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">Dr.
</span><span style="font-size:22.0pt;font-family:"Cambria",serif">Lili Wang </span>
</p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;text-align:center">
<span style="font-size:22.0pt;font-family:"Cambria",serif;color:black"> </span><span style="font-size:22.0pt;font-family:"Cambria",serif">Associate Professor
<span style="color:black"> </span></span></p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal" align="center" style="text-align:center"><img width="300" height="300" style="width:3.125in;height:3.125in" id="Picture_x0020_3" src="cid:image001.jpg@01D81833.30C8BBD0" alt="Zhengshan Chen"></p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black;background:white">Department of Systems Biology</span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">City of Hope
</span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:24.0pt;font-family:"Cambria",serif"> </span></p>
<p class="MsoNormal" align="center" style="text-align:center"><i><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">“</span></i><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">RNA splicing dysregulation and oncogenesis</span><span style="font-size:22.0pt;font-family:"Cambria",serif">”</span></p>
<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><span style="font-size:22.0pt"> </span></p>
<p class="MsoNormal"> <i> </i></p>
<p class="MsoNormal" align="center" style="text-align:center"><i> </i></p>
<p class="MsoNormal" align="center" style="text-align:center"> <b><span style="font-size:20.0pt;font-family:"Cambria",serif">Wednesday,
<span class="xapple-converted-space">February 2</span>, 2022</span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;background:white"><b><span style="font-size:20.0pt;font-family:"Cambria",serif;color:black">4:00 p.m. – 4:50 p.m.</span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;background:white"><span style="color:black"> </span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="color:black">Virtual Seminar</span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b> </b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:11.5pt;color:black">Join Zoom Meeting</span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt"><a href="https://ucr.zoom.us/j/91696732190?pwd=T1dOWTRRbitjOHdJbzAxYWMrNUxJdz09">https://ucr.zoom.us/j/91696732190?pwd=T1dOWTRRbitjOHdJbzAxYWMrNUxJdz09</a></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;color:black">Meeting ID: 916 9673 2190</span></p>
<p class="MsoNormal" align="center" style="margin-bottom:12.0pt;text-align:center">
<span style="font-size:12.0pt;color:black">Passcode: 563391<br>
<br>
</span> </p>
<p class="MsoNormal" align="center" style="text-align:center;background:white"><span style="color:black"> </span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><i><span style="font-size:14.0pt;color:black">Host: Dr. Zhenyu Jia</span></i></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><i><span style="font-size:14.0pt">zhenyuj@ucr.edu</span></i></p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal" align="center" style="text-align:center"> </p>
<p class="MsoNormal"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Abstract: Worldwide large-scale cancer genome sequencing efforts have identified recurrent RNA splicing factor mutations in multiple types of cancer including chronic
lymphocytic leukemia (CLL). All these mutations cause genome-wide aberrant RNA splicing, raising up a question on how RNA splicing dysregulation contributes to cancer biology. Using CLL as a disease model, I will discuss our strategies used to discover impacts
of splicing factor mutation on leukemogenesis as well as our understanding on how RNA epigenetics regulates splicing.</span></p>
<p class="MsoNormal"> </p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="color:black"> </span> </p>
<p class="MsoNormal"> </p>
<p class="MsoNormal"> </p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif">-- </span></p>
<div>
<p class="MsoNormal"><b><i><span style="font-family:"Times New Roman",serif">Mariella J. Valdivia
</span></i></b></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">Administrative Officer, Botany & Plant Sciences</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">2118 Batchelor Hall
</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">University of California
</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">Riverside, CA 92521-0124</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif"> </span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">Phone: (951)827-4619</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif">Fax: (951)827-4437</span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif"> </span></i></p>
<p class="MsoNormal"><b><i><span style="font-size:10.0pt;font-family:Helvetica;color:#234674;background:silver">We are working remotely for the duration of the campus closure. I am working regular business hours and will respond to e-mails as quickly as possible.</span></i></b></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif"> </span></i></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif"> </span></i></p>
<p class="MsoNormal"> </p>
<p class="MsoNormal"><span style="font-family:"Times New Roman",serif"> </span></p>
</div>
<p class="MsoNormal"> </p>
</div>
</div>
</body>
</html>