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<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><b><span style="font-size:24.0pt;font-family:"Cambria",serif;color:black">CMDB/GGB/MCBL Seminar Program</span></b><o:p></o:p></p>
<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><i><span style="font-size:20.0pt;font-family:"Cambria",serif">Fall<span style="color:black"> 2020</span></span></i><o:p></o:p></p>
<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><i><span style="font-size:24.0pt;font-family:"Cambria",serif;color:#2F5597">Presented during the 10<sup>th</sup> Annual Southern California Eukaryotic Pathogen Symposium</span></i><o:p></o:p></p>
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<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Cambria",serif"><img width="230" height="203" style="width:2.3958in;height:2.1145in" id="Picture_x0020_2" src="cid:image001.jpg@01D6A3D4.4DF75F60" alt="Dr. Photini Sinnis, Professor, Johns Hopkins Bloomberg School of Public Health"></span><o:p></o:p></p>
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<p class="MsoNormal" align="center" style="text-align:center"><b><i><span style="font-size:24.0pt;font-family:"Cambria",serif;color:black">Keynote Speaker:</span></i></b><b><span style="font-size:24.0pt;font-family:"Cambria",serif;color:black"> Dr. Photini
Sinnis</span></b><o:p></o:p></p>
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<b><span style="font-size:22.0pt;font-family:"Cambria",serif">Professor</span></b><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">|Johns Hopkins Bloomberg School of Public Health|</span><o:p></o:p></p>
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<b><i><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">Seminar Title:
</span></i></b><i><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black">“Establishment of Malaria Infection: Parasite Bottleneck and Point for Intervention”</span></i><o:p></o:p></p>
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<b><i><span style="font-size:12.0pt;font-family:"Cambria",serif;color:black">Abstract:</span></i></b><span style="font-size:12.0pt;font-family:"Cambria",serif;color:black">
</span><span style="font-size:12.0pt;font-family:"Cambria",serif">Malaria infection is initiated when Plasmodium sporozoites are inoculated by an infected mosquito as it searches for blood. Sporozoites are inoculated into the dermis and must enter the blood
circulation to reach the liver where they divide and establish infection in the mammalian host. This is an understudied area of the parasite’s lifecycle yet the target of antibodies generated by the only malaria vaccine candidate to show efficacy in Phase
III clinical trials. The goals of our research are to: 1) quantify sporozoite transmission dynamics; 2) understand the molecular interactions between the parasite and its mosquito and mammalian hosts that make this passage possible; 3) elucidate the role(s)
of the sporozoite’s major surface protein, CSP, as the parasite transitions from mosquito to mammalian host; 4) translate our findings to drug and vaccine development.</span><o:p></o:p></p>
<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><span style="font-size:26.0pt;font-family:"Cambria",serif;color:red">Wednesday, October 21<sup>st</sup>,<sup> </sup>2020</span><o:p></o:p></p>
<p align="center" style="margin:0in;margin-bottom:.0001pt;text-align:center"><b><i><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black"> Time:</span></i></b><b><span style="font-size:22.0pt;font-family:"Cambria",serif;color:black"> 12:00 – 12:50
p.m.</span></b><o:p></o:p></p>
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<b><span style="font-family:"Cambria",serif;color:black;background:yellow"> </span></b><o:p></o:p></p>
<p class="xmsonormal" align="center" style="text-align:center"><b><span style="font-family:"Cambria",serif;color:black;background:yellow">Join Zoom Meeting</span></b><span style="font-family:"Cambria",serif;color:black;background:yellow"><br>
<a href="https://ucr.zoom.us/j/97872332514?pwd=VHE0MklDc21jekNKdlN6dWF6V3ZBZz09">https://ucr.zoom.us/j/97872332514?pwd=VHE0MklDc21jekNKdlN6dWF6V3ZBZz09</a><br>
<br>
<b>Meeting ID:</b> 978 7233 2514<br>
<b>Passcode:</b> 627236</span><o:p></o:p></p>
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<span style="font-family:"Cambria",serif;color:black;background:yellow"> </span><o:p></o:p></p>
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<b><span style="font-family:"Cambria",serif;color:black;background:white">UCR Faculty Host:
</span></b><span style="font-family:"Cambria",serif;color:black;background:white">Dr. Karine Le Roch (<a href="mailto:karine.leroch@ucr.edu">karine.leroch@ucr.edu</a>)</span><o:p></o:p></p>
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