<div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><br><div dir="ltr"><div dir="ltr"><div dir="ltr"><div style="text-align:center"><img src="cid:ii_ma70feyr0" alt="IIGB logo.jpg" style="margin-right:0px"></div><div style="text-align:center"><font face="georgia, serif"><span style="color:rgb(7,55,99);font-size:20pt;font-weight:700">You are cordially </span><span style="color:rgb(7,55,99);font-size:20pt;font-weight:700">invited</span><span style="color:rgb(7,55,99);font-size:20pt;font-weight:700"> to attend</span></font></div><div style="text-align:center"><font face="georgia, serif" size="6"><b>Adam Caparco</b></font></div><div style="text-align:center"><b><font face="georgia, serif">Northeastern University</font></b></div><div style="text-align:center"><img src="cid:ii_ma70qq4v1" alt="Screenshot 2025-05-02 093849.jpg" width="390" height="391" style="margin-right:0px"><br></div><div style="text-align:center"><br></div><div style="text-align:center"><font face="georgia, serif"><b style="color:black;font-size:large;text-align:left">Date:</b><span style="color:black;font-size:large;text-align:left"> Friday, May 16</span></font></div><div style="text-align:center"><b style="font-family:georgia,serif;font-size:large;color:black;text-align:left">Time:</b><span style="font-family:georgia,serif;font-size:large;color:black;text-align:left"> 12pm - 1:00 pm</span></div><div><div style="text-align:center;direction:ltr;line-height:1.2;margin-top:0.5pt;margin-right:48.8pt;margin-bottom:0px"><font face="georgia, serif"><span style="text-align:left;font-size:large;color:black">             </span><b style="text-align:left;font-size:large;color:black">Location: </b><span style="text-align:left;font-size:large;color:black">Genomics Auditorium 1102</span></font></div><div style="text-align:center;direction:ltr;line-height:1.2;margin-top:0.5pt;margin-right:48.8pt;margin-bottom:0px"><span style="text-align:left;font-size:large;color:black"><font face="georgia, serif"><br></font></span></div><div style="text-align:center;direction:ltr;line-height:1.2;margin-top:0.5pt;margin-right:48.8pt;margin-bottom:0px"><span style="text-align:start"><font face="georgia, serif"><span style="color:rgb(0,0,0);font-size:16px">              </span><font size="4" color="#073763"> <b> </b><b>   Engineering Tobacco Mild Green Mosaic Virus for Crop Protection</b></font></font></span></div><div style="text-align:center;direction:ltr;line-height:1.2;margin-top:0.5pt;margin-right:48.8pt;margin-bottom:0px"><b style="text-align:left;color:rgb(7,55,99)"><font face="georgia, serif" size="4"> </font></b></div><div style="text-align:center;direction:ltr;line-height:1.2;margin-top:0.5pt;margin-right:48.8pt;margin-bottom:0px"><div style="text-align:center"><font face="georgia, serif" size="4" color="#000000"><b style="text-align:start">           Abstract: </b></font></div></div></div><div style="text-align:left"><span style="color:rgb(0,0,0);font-size:16px"><font face="georgia, serif">Despite being a plant pathogen to a limited number of hosts, tobacco mild green mosaic virus (TMGMV) offers innovative solutions for crop protection as an engineered nanocarrier. Our research demonstrates that TMGMV can be thermally transformed into spherical nanoparticles (SNPs) capable of efficiently encapsulating agrochemicals. These SNPs show good mobility through soil while protecting cargo from adsorption, enabling delivery of hydrophobic agrochemicals. Using a gel burrowing assay, we demonstrated the efficacy of SNP-delivered ivermectin against nematodes after the formulations passed through soil, whereas free ivermectin became soil-adsorbed and ineffective. Building on this platform, we are now exploring TMGMV's ability to deliver nucleic acids into plant cells for immunoengineering applications. This emerging approach aims to transiently activate plant defense pathways against pathogens without permanent genetic modification, potentially providing prophylactic protection comparable to immune priming.</font></span></div></div></div></div></div></div></div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><p class="MsoNormal"><font face="arial, sans-serif"></font></p></div></div></div>
</div>