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<span style="font-family: Tahoma, sans-serif; font-size: 20pt; color: rgb(0, 60, 165); font-weight: 700;"> You are cordially
</span><span style="font-family: Tahoma, sans-serif; font-size: 20pt; color: rgb(23, 78, 134); font-weight: 700;">invited</span><span style="font-family: Tahoma, sans-serif; font-size: 20pt; color: rgb(0, 60, 165); font-weight: 700;"> to attend</span></p>
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<span style="font-family: "Book Antiqua", serif; font-size: 24pt; color: black;"> Ailong Ke</span></p>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 18pt; color: rgb(0, 74, 172);">
</span><span style="font-family: "Gill Sans", sans-serif; font-size: 16pt; color: rgb(0, 74, 172);"> Professor of Molecular Biophysics and Biochemistry</span></p>
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Yale University</div>
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<span style="line-height: 1.2;"><img id="x_x_image_0" width="292" height="439" style="width: 292px; height: 439px; max-width: 1249px; margin: 0px;" src="https://lh7-rt.googleusercontent.com/docsz/AD_4nXfxc4vckgaNMlTr9X0ad6BIz5tWtDwc2J-H1qo8Aafr9lskl50DahqbXVqfPuWtMjoiz1tXVwCKVh1IADJiaHM6Q-LnOOVAw77PhsbgNL0w_cbflrAVdDdynWWPIJrFxsTgaIVa08JieayLc62S7zvjUjzOn-GHpKh0S22LCw?key=gYosQY6bfJcPXvpshzGM7NEx"></span></div>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 18pt; color: rgb(0, 74, 172); background-color: white;">Leveraging mechanistic insights for CRISPR tool development</span></p>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 16pt; color: black;"> </span><span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: black;"> Date: Friday, November 8</span></p>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: black;"> Time: 12pm - 1:00 pm</span></p>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: black;"> Location: Genomics Auditorium 1102</span></p>
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<span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: rgb(67, 67, 67); font-weight: 700;">Abstract:</span><span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: rgb(67, 67, 67);"> </span><span style="font-family: "Gill Sans", sans-serif; font-size: 12pt; color: black;">We
are in the middle of a revolution driven by CRISPR science. Researchers used to cheer for every new CRISPR system that leaves a mark on the genetic material. We now strive for tools that enable genetic operations that are never found in nature. My laboratory
strives to develop new editing tools from mechanistic insights. I will tell a few stories on how we derive molecular mechanisms from the CRISPR systems using high-resolution biophysical methods. I will then move on to discuss ways to leverage the mechanistic
understanding for genome editing tool development.</span></p>
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