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<span style="font-family: Tahoma, sans-serif; font-size: 38pt; color: rgb(255, 184, 27);"><b>Institute of Integrative Genome Biology Seminar</b></span></p>
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<span style="font-family: Tahoma, sans-serif; font-size: 20.5pt; color: rgb(0, 60, 165);"><b>You are cordially invited to attend:</b></span></p>
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<span style="font-family: "Book Antiqua", serif; font-size: 25pt;">Joy Xiang</span></p>
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<span style="font-family: Tahoma, sans-serif; font-size: 17.5pt; color: rgb(0, 74, 172);">UCR School of Medicine</span></p>
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<span style="font-family: Tahoma, sans-serif; font-size: 17.5pt; color: rgb(0, 74, 172);"><img style="margin-top: 0px; margin-bottom: 0px; max-width: 100%;" id="image_0" data-outlook-trace="F:1|T:1" src="cid:f7d00425-1c41-461b-a8d5-421171ac7f19"></span></p>
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<span style="font-size: 22pt; color: rgb(0, 74, 172); line-height: 116%;">Illuminating Hidden RNA Regulatory Landscapes of SARS-CoV-2 Proteins</span></p>
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Date: Friday, September 27th</p>
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Time: 12:00 – 1:00 pm</p>
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Location: Genomics Auditorium 1102A</p>
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<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-size: 11pt;"><b>Abstract:</b>
</span><span style="font-family: "Times New Roman", serif; font-size: 11pt;">COVID-19 is caused by SARS-CoV-2, a positive-sense, single-stranded RNA virus that operates primarily at the post-transcriptional level. Its genome encodes RNA-binding proteins and
effectors that regulate replication, transcription, translation, and the interplay with the host immune response. While cellular RNA-binding proteins facilitate both viral biosynthesis and antiviral effects, less is known about virus protein interactions with
host transcriptome. To address this, we systematically mapped these interactions integrating data from protein-RNA interaction sequencing (eCLIP), translatomics (RiboSTAMP) and reporter assays.</span></p>
<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Times New Roman", serif; font-size: 11pt;"> We profiled the RNA interactions of key SARS-CoV-2 proteins, including nucleocapsid (N), primase (NSP8), and RNA-dependent
RNA polymerase (RdRP/NSP12), discovering novel sites that mediate translation and infection rates. Surprisingly, RdRp showed widespread interactions with host RNAs. Further profiling of SARS-CoV-2 proteome revealed that about half of the viral proteins are
RNA-binding, contributing to global transcriptional and translational repression, and mRNA export inhibition, dampening the host immune response. Our findings highlight new regulatory roles for viral proteins, presenting exciting opportunities for therapeutic
development.</span></p>
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<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Calibri Light", sans-serif; color: black;">Best, </span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Calibri Light", sans-serif; color: rgb(32, 33, 36);">Mauricio Macias-Serrano </span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Calibri Light", sans-serif; color: rgb(179, 106, 226);"><i>Financial Analyst 1</i></span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Calibri Light", sans-serif; color: rgb(32, 33, 36);">1206 Genomics Bldg
</span><span style="font-family: "Calibri Light", sans-serif; color: rgb(32, 33, 36); background-color: white;">|</span><span style="font-family: "Calibri Light", sans-serif; color: rgb(32, 33, 36);"> IIGB | University of California, Riverside</span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: "Calibri Light", sans-serif; color: rgb(32, 33, 36);">P: 951-827-2601 | mmaci023@ucr.edu</span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="color: black; background-color: white;"><a href="https://iigb.ucr.edu/" id="OWA3bf90901-baf8-855b-810b-f23dd0edc3a9" class="x_OWAAutoLink" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;"><img width="153" height="36" style="width: 153px; height: 36px; margin-top: 0px; margin-bottom: 0px;" data-outlook-trace="F:2|T:2" src="cid:276500a3-dc7d-43b5-94c5-ca121b9398ed"></a><a href="https://cepceb.ucr.edu/" id="OWA3b2dbb9e-c20f-53eb-c49b-df8ea87a988d" class="x_OWAAutoLink" data-auth="NotApplicable" style="margin-top: 0px; margin-bottom: 0px;"><img width="91" height="39" style="width: 91px; height: 39px; margin-top: 0px; margin-bottom: 0px;" data-outlook-trace="F:2|T:2" src="cid:2dcf01f5-649d-4fac-95f6-98ac5acc2cb0"></a></span></p>
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