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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">Dear colleagues,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">I am excited to share some exciting news regarding the enhanced capabilities of the IIGB Multiomics Core Facility at our campus. Our facility now offers advanced services in metabolomics,
proteomics, data analyses, genomics, and bioinformatics (see below).<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">This expansion represents a significant milestone for our research community. Thanks to the diligent and hard work of the core staff, the cores are now able to provide researchers
across disciplines with access to cutting-edge technologies and expertise, empowering them to delve deeper into their scientific inquiries and accelerate discoveries.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">The inclusion of metabolomics, proteomics, genomics, and bioinformatics services signifies our commitment to providing comprehensive support for diverse research projects. Whether
you are studying metabolic pathways, protein interactions, genomic variations, or complex data analysis, our facility is equipped to meet your needs.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">I encourage you to explore the expanded services offered by the IIGB Multiomics Core Facility and leverage these resources to advance your research endeavors. Together, we can continue
to push the boundaries of scientific exploration and innovation.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">Be powerful<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif">Katie<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Metabolomics:<o:p></o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Measurement of volatile compounds (Headspace-SPME). <o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Upgraded GC-MS platform in 2023 with Headspace Solid Phase Micro Extraction capabilities, boosting analytical capabilities for volatile compounds. <o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Metabolite imaging (MALDI-TOF).<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Acquired new MS imaging source for the Synapt G2si in December 2023, enabling MS imaging experiments for metabolite abundance mapping in biological and synthetic sample sections.<o:p></o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Proteomics:<o:p></o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Protein Post-Translational Modification (PTM) Analysis<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">High Selectivity and Sensitivity Targeted Proteomics<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Data-Independent Acquisition (DIA) Proteomics (Opening Soon)<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Protein Purification<o:p></o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Genomics:<o:p></o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Acquisition of advanced instruments including Illumina NextSeq 2000 Sequencing Platform, Oxford Nanopore MinION and Flongle Sequencing Platforms, and more.<o:p></o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Bioinformatics:<o:p></o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Addition of single-cell RNA-seq analysis to services, alongside RNA-seq and ChIP-seq.<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Note: </span><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Open bioinformatics office hours (2-3 PM Daily via Calendly appt).<o:p></o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:"Times New Roman",serif">Data Analysis:<o:p></o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Introduced Parallel Fold-Change Analysis method, supported by ShowMEPATH tool, automating pathway generation and facilitating large-scale comparisons in biological research. ShowMEPATH expedites
analysis of metabolite or transcript changes, offering efficient insights into complex dataset patterns. Its automation manages expanding biological data scale, while the Parallel Fold-Change Plot enhances interpretation of complex dataset relationships. ShowMEPATH
ensures meaningful interpretation in complex biological comparisons.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none">Katayoon (Katie) Dehesh<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none">Director, Institute for Integrative Genome Biology, Distinguished Professor
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none">Ernst and Helen Leibacher Endowed Chair in Botany and Plant Sciences<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none">University of California, Riverside, CA 92521<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none">Phone: (951) 827-6370; Fax: (951) 827-5155<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#1F497D;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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