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<!--StartFragment--><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Dear Katie and IIGB faculty, <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify;line-height:11.55pt"><font face="Arial" class="">While I think both
the Nanopore GridION and the Orbitrap ASCEND would be great additions
to the cores, the question posed to the faculty in the survey/vote did not
contain all the information needed to make an informed decision. <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify;line-height:11.55pt"><font face="Arial" class="">Hence, before the
faculty vote on how best to use the lottery funds, I would like to let the IIGB
faculty know what we accomplished this past year while Xuemei was the IIGB
interim director while Katie was on sabbatical. <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify;line-height:11.55pt"><font face="Arial" class="">As many of you
know, our Genomics core was outdated and nonfunctional. Xuemei, together with
Julia, the staff at the core and myself, generated a list of instruments that
were critical to reviving the core. <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify;line-height:11.55pt"><font face="Arial" class=""><i class="">The
NextSeq2000, together with other smaller instruments, were listed as essential
for the day-to-day activity of the core and are the bread and butter of the
Genomics core. </i><i class=""><o:p class=""></o:p></i></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Xuemei, together with Weifeng Gu and Sean
O’Leary, managed to secure new NIH funding to bring to the core 1) a new <span style="color:#222222" class="">Typhoon RGB Imager, 2) a new Luminometer (Plate reader);
and 3) a Tapestation (similar as </span>Qsep 100<span style="color:#222222" class="">). <o:p class=""></o:p></span></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><font face="Arial" class=""><i class=""><span style="color: rgb(34, 34, 34);" class="">Please
join me in thanking </span></i><i class="">Xuemei,
Weifeng Gu and Sean O’Leary<span style="color:#222222" class=""> for their
hard work!</span></i><i class=""><o:p class=""></o:p></i></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><span style="color: rgb(34, 34, 34);" class=""><font face="Arial" class="">In addition, Xuemei, Julia and I lobbied
the upper administration and secured additional funds ($530K, aka lottery funds)
for the Genomics Core, including funds for the NextSeq2000. <o:p class=""></o:p></font></span></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><span style="color: rgb(34, 34, 34);" class=""><font face="Arial" class="">These
funds will modernize the Genomics Core and make it truly functional once again.<o:p class=""></o:p></font></span></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><span style="color: rgb(34, 34, 34);" class=""><font face="Arial" class="">This
is critical for the success of many faculty on campus as well as our PhD
students (lottery funds can only be spent on items that benefit the students)<o:p class=""></o:p></font></span></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><span style="color: rgb(34, 34, 34);" class=""><font face="Arial" class="">With
the lottery funds we can also purchase small instruments essential for sample
preparation (Bioruptor) as well as the nanopore for long read sequencing.
<o:p class=""></o:p></font></span></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><b class=""><span style="color: rgb(34, 34, 34);" class=""><font face="Arial" class="">We have a critical decision to make
now:<o:p class=""></o:p></font></span></b></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class=""><span style="color: rgb(34, 34, 34);" class="">If the IIGB faculty decide to get
the </span>Orbitrap ASCEND (over 1
million dollars) with the funds initially targeted for the Genomics
Core, there will be no money left for any small instruments nor any new
sequencing platforms. <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><font face="Arial" class="">Please keep in mind
that we cannot get small instruments through instrument grants. <o:p class=""></o:p></font></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><font face="Arial" class=""><i class="">In short, by
diverting the lottery funds to the new mass spectrometer, the Genomics core
will be nonfunctional and would eventually disappear. </i><i class=""><o:p class=""></o:p></i></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Furthermore, after several years without a
fulltime Academic Coordinator for the Genomics Core, we finally recruited Dr.
Wei Zhang, Ph.D<b class="">. </b> <o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><font face="Arial" class=""> <i class="">Julia Bailey-Serres, Sydney Glassman,
Quinn McFrederick and I, were part of the search committee, and we were thrilled
to recruit Wei to UCR this Spring. <o:p class=""></o:p></i></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><font face="Arial" class="">If you have not met
Wei yet, please take some time to do so now. She is fantastic! <o:p class=""></o:p></font></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><font face="Arial" class="">Wei and I already
submitted a new NIH instrument Grant for a NOVAseq platform.<o:p class=""></o:p></font></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><i class=""><font face="Arial" class="">With proper
instrumentation in the Genomics Core, Wei will be able to enable all of our research.<o:p class=""></o:p></font></i></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in;text-align:justify"><font face="Arial" class=""><i class=""> I am sure she will be happy to help any of us with
additional instrumentation grants. </i><i class=""><o:p class=""></o:p></i></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">We worked hard this past year to convince the
upper admin of the importance of reviving the Genomics Core. If we do not take
this opportunity now, it will not come again and I fear that the Genomics Core
will disappear altogether. In contrast, a new mass spectrometer can be funded
through instrumentation grants as noted above.<o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Thank you all for your support,<o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Best,<o:p class=""></o:p></font></p><p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
text-align:justify"><font face="Arial" class="">Karine</font><o:p class=""></o:p></p>
<!--EndFragment--><div><br class=""><blockquote type="cite" class=""><div class="">On Aug 26, 2022, at 11:55 AM, Katayoon Dehesh <<a href="mailto:katayoon.dehesh@ucr.edu" class="">katayoon.dehesh@ucr.edu</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Dear Colleagues,<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">The Dean informed me yesterday that the total lottery funds awarded to IIGB is $530K. This money can be spent for the purchase of any instrumentations with greater impacts on teaching and research activities, albeit with a more focused view on the teaching outcome.<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">There are two groups of instruments that fulfill the required criteria for the funds:<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><ol start="1" type="1" style="margin-bottom: 0in; margin-top: 0in;" class=""><li class="MsoListParagraph" style="margin: 0in 0in 0in 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; line-height: 15.399999618530273px;"><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: Georgia, serif;" class=""> 10X Chromium: an instrument for single-cell genomics, bundled with<span class="Apple-converted-space"> </span></span><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: Georgia, serif; color: windowtext;" class="">GridION</span><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: Georgia, serif;" class="">, a high-throughput long-read sequencer.<o:p class=""></o:p></span></li></ol><div style="margin: 0in 0in 0in 0.75in; font-size: 11pt; font-family: Calibri, sans-serif; line-height: 15.399999618530273px;" class=""><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><ol start="2" type="1" style="margin-bottom: 0in; margin-top: 0in;" class=""><li class="MsoListParagraph" style="margin: 0in 0in 0in 0.25in; font-size: 11pt; font-family: Calibri, sans-serif;"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Orbitrap ASCEND mass spectrometer for high resolution proteomics and metabolomics. For this instrument we will need an extra 100K, however the Dean added that we will go to the provost to secure the amount.<o:p class=""></o:p></span></li></ol><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Rather than making a unilateral decision, I am reaching out to ask for your input. It is important that we purchase the instrument with highest impact for most of our community. To better assess your needs, I am sending the link below where you can state the choice of your preferred instrument. <o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><a href="https://docs.google.com/spreadsheets/d/1dR_moNhfllQmImap9_ik_CDHWDhE7cYzB56kLVKqB_4/edit?usp=sharing" style="color: rgb(5, 99, 193); text-decoration: underline;" class="">https://docs.google.com/spreadsheets/d/1dR_moNhfllQmImap9_ik_CDHWDhE7cYzB56kLVKqB_4/edit?usp=sharing</a><o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Please provide your responses not later than the next Thursday September 1<sup class="">st</sup>. I will let you know outcome.<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Be powerful and thanks in advance for your input.<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Katie<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class="">Katayoon (Katie) Dehesh<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class="">Director, Institute for Integrative Genome Biology, Distinguished Professor<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class="">Ernst and Helen Leibacher Endowed Chair in Botany and Plant Sciences<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class="">University of California, Riverside, CA 92521<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class="">Phone: (951) 827-6370; Fax: (951) 827-5155<o:p class=""></o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 12pt; font-family: Georgia, serif; color: rgb(31, 73, 125);" class=""><o:p class=""> </o:p></span></div><div style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div></div><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">_______________________________________________</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">IIGB_All mailing list</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><a href="mailto:IIGB_All@lists.ucr.edu" style="color: rgb(5, 99, 193); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; 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<div>K. Le Roch, PhD<br class="">Professor of Molecular, Cell and Systems Biology<br class="">Director Center for Infectious Disease and Vector Research<br class="">Institute for Integrative Genome Biology<br class="">Department of Molecular, Cell and Systems Biology (MCSB)<br class="">University of California Riverside<br class="">900 University Avenue<br class="">Multidisciplinary Research Building (MRB) Room 3139<br class="">Riverside, CA 92521, USA<br class="">Phone office: (1) 951 827 54 22<br class="">Phone Lab: (1) 951 827 5934<br class="">Web Site: <a href="http://www.lerochlab.ucr.edu/" class="">http://www.lerochlab.ucr.edu/</a><br class=""></div><div class=""><br class=""></div><br class="Apple-interchange-newline">
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