[IIGB_All] IIGB Seminar: Daniel Voytas 2/20/26 *FRIDAY*

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*Daniel Voytas*
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*  From Lab to Field: Realizing the Promise of Plant Gene Editing at Scale*

*               Date:* Friday, February 20

*               Time:* 12:00 pm-1:00pm

*               Location: *Genomics Auditorium 1102


*Abstract:*
Plant gene editing is usually carried out by delivering reagents such as
Cas9 and sgRNAs to explants in culture. Edited cells are then induced to
differentiate into whole plants by exposure to various hormones. Creating
edited plants through tissue culture is often inefficient, requires
considerable time, only works with limited species and genotypes and causes
unintended changes to the genome and epigenome. We have been pursuing
alternative approaches for plant gene editing that minimize or obviate the
need for tissue culture. In one approach, we generate gene edited
dicotyledonous plants through de novo meristem induction. Developmental
regulators and gene editing reagents are delivered to somatic cells on
whole plants. Meristems are induced that produce shoots with targeted DNA
modifications, and gene edits are transmitted to the next generation. In a
second approach, we use RNA viruses to deliver sgRNAs through infection to
transgenic plants that express Cas9. The sgRNAs are augmented with
sequences that promote cell-to-cell mobility and movement into the
meristem. Gene edited shoots are thus generated that transmit gene edits to
the next generation. Because both approaches minimize the need for tissue
culture, they promise to help overcome this bottleneck in plant
gene-editing.
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