[IIGB_All] IIGB Seminar: Robin Buell 1/31

[Aaliyah Kelley]

[cid:08ebe88b-5118-49dd-9bec-8a608c39ef7e]

You are cordially invited to attend

     Robin Buell

      University of Georgia


Complexity of plant natural product biosynthesis revealed through single cell multi-omics

[https://lh7-rt.googleusercontent.com/docsz/AD_4nXdT4Vh3KQXXbWfY7SJ4RLkidWx02eDMriKm4UUnI-VunZlLe2CstEP6Hv2vxh08q8X99h0LDtoSbe-uMEczG1x6s9-410d_HTtc8-HmYSekvh0tWS_rCnSZBtcSgMWuScgK1QbxbelEByQZOe1CXuE?key=qvgkn5Dc010sslj4qEFFn1Z2]

        Date: Friday, January 31

     Time: 12pm - 1:00 pm

      Location: Genomics Auditorium 1102


Abstract:

Plants and their natural products have been harnessed by humans for millennia for their health promoting activities, insecticidal and anti-microbial activities, as well as fragrance and food additive properties. These natural products, or specialized metabolites, have diverse functions in plants as pollinator attractants, defense and signaling molecules, and components of cell walls. The sheer diversity of specialized metabolites in plants is attributable to the dynamics of gene and genome evolution which are catalysts of species diversification. The advent of genomics technologies has revolutionized the discovery of the genes encoding specialized metabolites revealing a myriad of genome features and evolutionary mechanisms that underlie extant chemodiversity. For example, nearly the entire pathway for vinblastine and vincristine biosynthesis in Catharanthus roseus (Madagascar perwinkle) leaves has been resolved using gene expression profiling coupled with transcriptome and genome sequences over the last 15 years. Access to single cell -omics technologies, has revealed exquisite cell type specificity in the biosynthesis of monoterpene indole alkaloids in Madagascar perwinkle and aided in the identification of additional regulatory and structural sequences involved in the biosynthesis, transport and storage of vinblastine and vincristine biosynthesis thereby providing the foundation for understanding the evolution of cell-type specific gene expression.


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