[IIGB_All] *FRIDAY* IIGB Seminar: Junjie Guo

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You are cordially invited to attend
Junjie Guo
*Yale University*

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*Date:* Friday, April 25
*                 Time:* 12pm - 1:00 pm
             *Location: *Genomics Auditorium 1102

*          RNA Plasticity in Neuronal Health and Disease*

*Abstract: *
Over 50 neurological disorders have been linked to the instability and
expansion of tandem repeats, many of which are located within noncoding
regions of the genome. In this seminar, I will discuss our ongoing effort
in understanding the pathogenic mechanism of a hexanucleotide repeat
expansion within the first annotated intron of the C9ORF72 gene underlying
nearly half of the inherited cases of amyotrophic lateral sclerosis (ALS)
and frontotemporal dementia (FTD). I will also discuss our new line of work
on identifying the roles of alternative mRNA translation in diversifying
the localization and functions of synaptic proteins.
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