[UCR_DataScience] REMINDER: Data Science talk by Prof. Vasileios Christopoulos, tomorrow Friday October 14th, 12:15-1:15pm, MRB Seminar Room

[tsotras at cs.ucr.edu]

Reminder for the Data Science talk tomorrow Friday by Prof. Vasileios
Christopoulos. Note that we will start at 12:15pm (MRB Seminar room).

Please register using the link below if you plan to attend.

Sincerely,
V. Tsotras

-------------------------------------------------------
> Our next Data Science seminar will be next Friday, October 14th, 2022 at
> the MRB Seminar Room (1st floor).
>
> Please note that this seminar will start at **12:15pm**.
>
>
> **** Pizza and refreshments will be provided ****
>
> To keep track of the number of attendees, please *register* at:
> https://www.eventbrite.com/e/data-science-talk-tickets-437558307677
>
>
> The talk will be given by Prof. Vasileios Christopoulos, Department of
> Bioengineering, UCR
>
> Title:
> Functional Ultrasound Imaging (fUSI): A game changer in neuroscience and
> medicine
>
>
> Abstract:
>
> Recent advances in neuroimaging technology have significantly contributed
> to a better understanding of human brain organization, and the development
> and application of more efficient clinical programs. However, the
> limitations and tradeoffs inherent to the existing techniques, prevent
> them from providing large-scale imaging of neural activity with high
> spatiotemporal resolution, deep penetration, and specificity in awake and
> behaving participants.
>
> Recently, functional ultrasound imaging (fUSI) was introduced as a
> revolutionary technology that provides a unique combination of spatial
> coverage, unprecedented spatiotemporal resolution (~100 μm and ~100
> ms) and compatibility with freely moving animals. While fUSI is a
> hemodynamic technique, its superior spatiotemporal performance and
> single-trial sensitivity offer a substantially closer connection to the
> underlying neuronal signals than achievable with other hemodynamic methods
> such as fMRI. In addition, the relative simplicity and portability of
> ultrasound have allowed fUSI to be performed in awake and behaving
> animals, providing minimally invasive neural imaging in species ranging
> from mice to humans. In vivo fUSI was first reported in 2011 by imaging
> cerebral blood volume (CBV) changes in the micro-vascularization of the
> rat brain during whisker stimulation. Since then, this technique has been
> applied to brain activity imaging during olfactory stimuli, resting state
> connectivity, behavioral tasks on freely moving rats, non-human primates
> (NHPs) and other animals. However, one of the great advantages of fUSI is
> the ability to detect hemodynamic changes of only 2% without averaging
> over multiple trials. The ability to rely on the accuracy of a
> single-trial is necessary if one intended on using functional ultrasound
> signal to detect moment-to-moment variations of the blood flow.
>
> By taking advantage of the excellent sensitivity of fUSI, our team
> performed single-trial motor experiments in awake and behaving non-human
> primates (NHPs). We recorded from outside the dura and above the posterior
> parietal cortex (PPC), while animals performed memory-delayed reach and
> eye (saccade) movements. We then used fUSI signal from the delay period
> before movement to decode the animal’s intended direction and effector. We
> showed for the first time that fUSI is capable of capturing the
> preparatory motor activity in NHPs that precedes movement responses – a
> prerequisite to brain-machine interfaces (BMIs), a key application that
> could benefit from this technology. These results are a critical step in
> the development of neuro-recording and brain interface tools that are less
> invasive, high resolution, and scalable.
>
> Recently, we took the next major leap in fUSI by extending this technology
> to study the pathophysiology of neuropsychiatric diseases in pre-clinical
> (pharmaco-fUSI, mouse model of schizophrenia) and clinical trials (i.e.,
> patients with traumatic brain injury, chronic back pain and others) and to
> develop modern neuromodulation strategies. Overall, fUSI provides
> researchers with truly revolutionary capabilities to study the central
> nervous system in a wide range of species, opening new avenues to
> understanding basic mechanisms of neuropsychiatric diseases and developing
> new treatments.
>
>
> ------------------------------------
> Sponsored by the UCR Data Science Center, the purpose of the Data Science
> Seminar is to foster collaborations between "core" Data Science faculty
> (from CSE/ECE/Stat Departments) and faculty/visitors from other sciences
> that face Data Science problems in their research. These informal
> gatherings are open to interested faculty and graduate students. Each
> meeting will start with a talk describing research problems and then a
> discussion will follow for questions, open problems, ideas for possible
> collaborations etc.
>
> A full list of previous seminars appears at:
> http://datascience.ucr.edu/seminars
>
> Please forward this email to other colleagues or graduate students in your
> lab that may be interested.
>
> Moreover, if you are interested in giving a Data Science related talk,
> please contact me.
>
> Sincerely,
> Vassilis Tsotras
> Professor, CSE Department
> Director, Data Science Major
>
>
> _______________________________________________
> DataScience mailing list
> DataScience at lists.ucr.edu
> https://lists.ucr.edu/mailman/listinfo/datascience
>