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<div style="text-align:center"><span style="color:#ffa500">April 2021</span></div>
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<h1 style="text-align:center;display:block;margin:0;padding:0;color:#033ddd;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:150%;letter-spacing:normal"><span style="color:#4b0082"><span style="font-size:20px"><strong>Announcements</strong></span></span></h1>
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<li style="text-align:justify">Dr. Mary Williams of the American Society of Plant Biologists. "How to talk about science: cultivate curiosity and inspire inquiry", Friday, noon April 9th. </li>
<li style="text-align:justify"><font color="#000000">Welcome to the Plants3D 2021 fellow cohort!</font></li>
<li style="text-align:justify"><span style="color:#000000">Community Member Highlight: Assistant Professor Yanran Li and Ph.D. candidate Angie Zhou</span></li>
<li style="text-align:justify">Plants3D's course, Product Design and Entrepreneurship for Agricultural and Biological Applications (BPSC/CEE208), has room for a few more students or serious auditors. T/TH 4-5:30 3 units</li>
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<td valign="top" class="m_8038127989898116458mcnTextContent" style="padding:0px 18px 9px;color:#222222;font-family:Arial,"Helvetica Neue",Helvetica,sans-serif;font-size:16px;word-break:break-word;line-height:150%;text-align:left">
<h1 style="text-align:center;display:block;margin:0;padding:0;color:#033ddd;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:150%;letter-spacing:normal"><span style="color:#4b0082"><span style="font-size:20px"><strong>Friday, April 9th noon, Plants3D Seminar</strong></span></span></h1>
<div style="text-align:center"><span style="font-size:18px">"How to talk about science: Cultivate curiosity and inspire inquiry."</span></div>
<h1 style="text-align:center;display:block;margin:0;padding:0;color:#033ddd;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:150%;letter-spacing:normal"><span style="color:#4b0082"><span style="font-size:20px"><strong>Dr. Mary Williams</strong></span><br>
<span style="font-size:18px"><strong>Invited by Taylor Myhre and the other Plants3D Fellows</strong></span></span></h1>
<div style="text-align:justify">The inspiring Dr. Mary Williams received her Ph.D. from the Rockefeller University and did a postdoc at UC Berkeley. She worked at Harvey Mudd College in Claremont, CA as a biology professor for 14 years before joining the American Society of Plant Biologists (ASPB) as Features Editor for <em>The Plant Cell</em> and the developer of Teaching Tools in Plant Biology. Mary actively mentors students via the Plantae platform (<a href="https://ucr.us1.list-manage.com/track/click?u=20258b97443c8dea22c17955f&id=992d51083f&e=f8eca9c9de" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">https://plantae.org/</a>), edits Plant Science Research Weekly (<a href="https://ucr.us1.list-manage.com/track/click?u=20258b97443c8dea22c17955f&id=0167841ea3&e=f8eca9c9de" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">https://plantae.org/research/wwrtw/</a>), and gives workshops on writing, teaching, and communication. You can follow Mary on Twitter via <a href="https://ucr.us1.list-manage.com/track/click?u=20258b97443c8dea22c17955f&id=54f79e5ed1&e=f8eca9c9de" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">@PlantTeaching</a></div>
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<td valign="top" class="m_8038127989898116458mcnTextContent" style="padding:0px 18px 9px;color:#222222;font-family:Arial,"Helvetica Neue",Helvetica,sans-serif;font-size:16px;word-break:break-word;line-height:150%;text-align:left">
<h1 style="text-align:center;display:block;margin:0;padding:0;color:#033ddd;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:150%;letter-spacing:normal"><font color="#4b0082"><span style="font-size:20px"><strong>Congratulations Plants3D 2021 Cohort!</strong></span></font></h1>
<div style="text-align:justify">We congratulate the new cohort of Plants3D trainees, who we will introduce in the May newsletter. Thanks to all students who applied for our program. If you are eligible but weren't selected, you are welcome to apply again next year! </div>
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<h1 style="text-align:center;display:block;margin:0;padding:0;color:#033ddd;font-family:Helvetica;font-size:40px;font-style:normal;font-weight:bold;line-height:150%;letter-spacing:normal"><font color="#000080"><span style="font-size:20px">Plants3D Community Member Profile</span></font></h1>
<div style="text-align:center"><span style="font-size:24px"><strong>Yanran Li</strong></span></div>
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<p style="text-align:justify;color:#222222;font-size:16px;margin:10px 0;padding:0;font-family:Helvetica;line-height:150%">Dr. Yanran Li is an Assistant Professor of Chemical and Environmental Engineering. Dr. Li obtained her Ph.D. in Chemical & Biomolecular Engineering at UCLA in 2012 under the guidance of Dr. Yi Tang. She was a postdoc in the group of Dr. Rustem Ismagilov at CalTech from 2012 to 2013, before a second postdoc in the group of Dr. Christima Smolke at Stanford University from 2013 to 2016. After the masterful reconstitution of the 10 enzyme pathway for noscapine biosynthesis from the opium poppy in yeast, Dr. Li joined UCR's CEE faculty and CEPCEB in 2016. Yanran is on the Plants3D Leadership team.</p>
<p style="text-align:justify;color:#222222;font-size:16px;margin:10px 0;padding:0;font-family:Helvetica;line-height:150%"><br>
In 2020, Yanran Li received the New Innovator Award from the National Institutes of Health’s High-Risk, High-Reward Research Program to discover and synthesize novel plant natural products of potential medicinal value. Visit <a href="https://ucr.us1.list-manage.com/track/click?u=20258b97443c8dea22c17955f&id=08daca9d9f&e=f8eca9c9de" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">Li LAB - Home (weebly.com)</a> to learn more about Yanran's lab.<br>
<br>
Cytochrome P450s (CYP450s) are enzymes involved in secondary metabolism and are essential to the natural product bioproduction in microbial systems.<br>
To know more about challenges in functional reconstitution of CYP450s in microbes, check out Plants3D fellow Anqi (Angie) Zhou and Professor Li's new review in <em>Current Opinion in Plant Biology</em> (<a href="https://ucr.us1.list-manage.com/track/click?u=20258b97443c8dea22c17955f&id=ad6bc8d40e&e=f8eca9c9de" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">https://doi.org/10.1016/j.pbi.2021.102005</a>)<br>
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Angie Zhou's dissertation focuses on the rational engineering of <em>S. cerevisiae</em> to efficiently synthesize valuable plant-derived terpenoids such as limonoids. Limonoids, produced by citrus, have a range of biological activities, including as anticancer agents. CYP450s are involved in multiple steps of the limonoid biosynthetic pathway. Angie is troubleshooting their functional reconstitution challenges due to their low catalytic activity, instability, dependence on CYP450 reductases, and the need for association with membranous structures. One strategy is the co-cultivation of <em>E. coli </em>and yeast to overcome these challenges.</p>
<p style="text-align:justify;color:#222222;font-size:16px;margin:10px 0;padding:0;font-family:Helvetica;line-height:150%">Angie remarked, "The experience of writing this review paper not only largely enriched my knowledge of rational design strategies but also helped me to understand better how to "plantize" microbial factories to increase production efficiency."</p>
<p style="text-align:justify;color:#222222;font-size:16px;margin:10px 0;padding:0;font-family:Helvetica;line-height:150%">Angie wrote about Dr. Yanran Li, "Dr. Li is a very nice, knowledgeable, and helpful mentor." She mentioned that they have open and effective communication. Dr. Li always gives her honest feedback about new ideas and provides constructive criticism, guidance, and encouragement during her research. <br>
<br>
Research in the Li group on limonoids is benefited by the citrus genomics projects in the labs of Dr. Danelle Seymour, Dr. Mike Roose, and the Dynamic Genome (Dr. Sue Wessler and Dr. Jim Burnette). </p>
<div style="text-align:center"><span style="font-size:12px">Photo on the left Dr. Danelle Seymour and Dr. Yanran Li and<br>
photo on the right: Dr. Yanran Li and Angie Zhou</span></div>
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<div style="text-align:center"><span style="font-size:20px"><span style="color:#800080"><strong>Trainee Information and Tips</strong></span></span></div>
<div style="text-align:center"><br>
Do you want your research or outreach to be featured on our website or in a newsletter? Do you want changes in your bio? Do you have an idea for the community to share? Do you want to feature your PI or a new paper? <br>
<br>
Please email the Plants3D NRT Program Coordinator, Maureen Hummel, about your accomplishments with "Plants3D product" as your subject.<br>
<br>
Be sure to acknowledge your NSF funding on every abstract, poster, and manuscript as follows:<br>
"Funded by the US National Science Foundation, DBI-1922642".<br>
<br>
<strong>Program Contacts</strong><br>
Julia Bailey-Serres,<br>
University Distinguished Professor,<br>
Botany and Plant Sciences<br>
<a href="mailto:serres@ucr.edu" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">serres@ucr.edu</a><br>
*<br>
Ian Wheeldon,<br>
Professor,<br>
Chemical and Environmental Engineering <br>
<a href="mailto:Ian.wheeldon@ucr.edu" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">Ian.wheeldon@ucr.edu</a><br>
*<br>
Maureen Hummel,<br>
Program Coordinator <br>
<a href="mailto:maureenh@ucr.edu" style="color:#007e9e;font-weight:normal;text-decoration:underline" target="_blank">maureenh@ucr.edu</a></div>
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