[CEPCEB_All] CEPCEB Seminar: Hong Ma TODAY

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*Hong Ma*
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*Identification and mechanisms of a novel plant RNA splicing factor
important for key floral transcripts and profiles of gene structures and
protein domains across angiosperms*


*             Date:* Thursday, November 6

*           Time:* 12:00 pm-1:00pm

*               Location: *Genomics Auditorium 1102


*Abstract:*

RNA splicing is a crucial step in gene expression and can affect
differential gene expression; however, relatively little is known about
factors and mechanisms regulating plant RNA splicing. At the same time, the
great majority of genes revealed by plant genomics lack known functions,
defined either genetically or biochemically. In an effort to identify novel
gene functions important for regulation of gene expression during plant
reproduction, we used an integrated approach with omics and functional
analyses to identify a novel factor, GRP20, for proper floral RNA splicing
and characterized its mechanisms as a newly discovered RNA-binding protein.
GRP20 is required for normal floral organ development and floral RNA
splicing, especially the proper retention of micro exons in floral homeotic
ABCE genes.  Thousands of micro exons are found in each of diverse plants
and in genes of a variety of functions. They are part of genes with
different exon-intron organizations and encode portions of a wide spectrum
of protein domains with different annotated functions. The lengths of many
micro exons are in multiple of 3 nucleotides, suggesting that alternative
splicing of these micro exons could lead to the production of protein
isoforms with varying activities. Profiling of these gene structure and
protein domain organizations across angiosperms suggests high degrees of
conservation, while micro exon-related changes have occurred in specific
lineages.  Both the functional and evolutionary genomic analyses highlight
the great need to probe gene functions at multiple levels, including
transcriptional and post-transcriptional, to gain further understanding of
gene regulation.
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