<div dir="ltr">Thanks Jim!<div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">---------- Forwarded message ---------<br>From: <strong class="gmail_sendername" dir="auto">Jim Llano</strong> <span dir="auto"><<a href="mailto:james.llano@ucr.edu">james.llano@ucr.edu</a>></span><br>Date: Thu, Oct 29, 2020 at 7:55 AM<br>Subject: New BASF unmet needs in Health and Nutrition and Enzyme technologies<br>To: Deborah Pagliaccia <<a href="mailto:deborahp@ucr.edu">deborahp@ucr.edu</a>>, Norman Ellstrand <<a href="mailto:ellstrand@ucr.edu">ellstrand@ucr.edu</a>><br></div><br><br>





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<p class="MsoNormal"><span style="color:#1f497d">Dear Deborah and Norm, <u></u><u></u></span></p>
<p class="MsoNormal"><span style="color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="color:#1f497d">Some of the below BASF “unmet needs” fall into areas of food and vitamins, and enzyme technologies which may resonate with the CAFÉ community.
<u></u><u></u></span></p>
<p class="MsoNormal"><span style="color:#1f497d"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="color:#1f497d">Thanks, Jim <u></u><u></u></span></p>
<p class="MsoNormal"><span style="color:#1f497d"><u></u> <u></u></span></p>
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<p class="MsoNormal"><b>From:</b> Christopher D Hewitt [mailto:<a href="mailto:christopher.d.hewitt@basf.com" target="_blank">christopher.d.hewitt@basf.com</a>]
<br>
<b>Sent:</b> Thursday, October 29, 2020 6:24 AM<br>
<b>Subject:</b> New BASF unmet needs in Health and Nutrition and Enzyme technologies<u></u><u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Hello<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">BASF has some new unmet needs in these areas, as listed below.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><u></u> <u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Please reach out to me if you have unique competence that could help us to address these needs or have specific questions.<u></u><u></u></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><u></u> <u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Leveraging synthetic biochemistry / cell free technologies for protein/enzyme production, strain optimization for heterologous expression and predictability of expression
<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Novel In silico models for predicting expressibility of large proteins / enzymes in microorganisms
<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Novel protein design approaches to predict improvement of enzyme molecule (substrate specificity, catalytic efficiency, temperature and biophysical stability in process/formulations)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Novel technologies for early stage prediction of fermentation process robustness, and scalability
<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Novel technologies for enzyme discovery<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Novel approaches for HTP automation and digitalization capabilities and workflows<u></u><u></u></span></p>
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<tr style="height:14.35pt">
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Replacement of porcine gelatin for tablets (e.g. biobased collagen)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Crosslinking of alginate without viscosity issues: improving loading capacity<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Use of chitosan for encapsulations - challenge is loading capacity and performance<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">How to make powders flow without nanoflow aids<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">New effective all-natural antioxidants<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Interactions of vitamins/carotenoids with natural polymers such as (partially) hydolyzed proteins, different starch types etc<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">New formulations improving bioavailability/ bioaccessibility of vitamins, carotenoids and other health ingredients<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">How to achieve performance level of modified starches with non-modified versions/mixtures<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Protein, hydrolysates and other natural polymers as emulsifiers in food<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Alternative natural foaming agents<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Egg substitution<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">New formats of micronutrient application in food fortification<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">New highly cost-effective formulation technologies<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Improvements in spray-drying (getting larger particles, less energy needed etc)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Spray-drying with assistance of electrical fields<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Low energy process for emulsifier production<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">A more sustainable cost-effective production of food grade Vitamin A and E compared with usual synthetic routes (e.g biobased intermediates in the process or final product)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Cost effective regulatory favorable natural ingredients (e.g. Vitamin B5, Vitamin B12, Vitamin D3, Carotenoids)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Avoiding formation of contaminants in production process and/or subsequent reduction (e.g. 3-MCPD, benzene, MOSH, MOAH etc)<u></u><u></u></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><u></u> <u></u></span></p>
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<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Kind regards<b><br>
Dr. Chris Hewitt, F.R.S.C.</b><br>
Innovation Network Manager<u></u><u></u></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><u></u> <u></u></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Phone: +1 734 324-6149, Mobile: +1 724 931-9069, Fax: +1 289 360-6001, Email:
<a href="mailto:christopher.d.hewitt@basf.com" target="_blank">christopher.d.hewitt@basf.com</a><br>
Postal Address: BASF Corporation, </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif">2 TW Alexander Drive</span>,
<span style="font-size:10.0pt;font-family:"Arial",sans-serif">27713 Research Triangle Park, USA<span style="color:black"><u></u><u></u></span></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-family:"Arial",sans-serif;color:black"><img border="0" width="201" height="114" id="m_3474136331983945703Picture_x0020_1" src="cid:175763e73d64cff311"><u></u><u></u></span></p>
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</div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><font size="2">Deborah Pagliaccia, Ph.D.</font></div><div dir="ltr">Professional Researcher, Department of  Microbiology and Plant Pathology<font size="2"><br></font></div><div dir="ltr"><font size="2"><font size="2">Managing Director, </font>California Agriculture and Food Enterprise - <a href="http://cafe.ucr.edu/" target="_blank">CAFÉ</a><br></font></div><div dir="ltr"><font size="2"><a href="http://globalfood.ucr.edu/" target="_blank">UCR Global Food Initiative</a> Co-Chair</font></div><div dir="ltr"><font size="2">University of California</font></div><div dir="ltr">Riverside, CA 92521<font size="2"><br></font></div><div dir="ltr"><br></div><div dir="ltr"><font color="#000000"><font size="2"><span style="font-family:"times new roman",serif"><a href="http://ccns.info/" target="_blank">California Citrus Nursery Society</a> CCNS </span></font><font size="2"><span style="font-family:"times new roman",serif">Executive Director</span></font></font><font size="2"><br></font></div></div></div></div></div></div></div>