[Bphystudent] Upcoming Biophysics Seminar by SSB

[Navaira Sherwani]

Dear All,

We are happy to announce the next seminar in our fortnightly series of
Biophysics Seminars coming up at the end of next week, during which Dr.
Weitao Chen from the Department of Mathematics will be giving a talk
featuring her work in Applied Mathematics. Details about the talk can be
found below:

*Location*: Student Success Center - Multi-Purpose Room 3 (Ground Floor)

*Date + Time*: Friday, February 23rd, from 2:00 PM - 3:00 PM

*Speaker*: Dr. Weitao Chen

*Title: *
*A Mechanochemical Coupled Model to Understand Budding Behavior in Aging
Yeast *
*Abstract: *Cell polarization, in which a uniform distribution of
substances becomes asymmetric due to internal or external stimuli, is a
fundamental process underlying cell mobility and cell division. Budding
yeast provides a good system to study how biochemical signals and
mechanical properties coordinate with each other to achieve stable cell
polarization and give rise to certain morphological change in a single
cell. Recent experimental data suggests yeast budding develops into two
trajectories with different bud shapes as mother cells become old. We first
developed a 2D model to simulate biochemical signals on a shape-changing
cell and investigated strategies for robust yeast mating. Then we extended
and coupled this biochemical signaling model with a 3D subcellular element
model to take into account cell mechanics, which was applied to investigate
how the interaction between biochemical signals and mechanical properties
affects the cell polarization and budding initiation. This 3D
mechanochemical model was also applied to predict mechanisms underlying
different bud shape formation due to cellular aging.

For those who cannot attend in person, this talk is also available online.
*Zoom Link:*
https://ucr.zoom.us/j/92738986667?pwd=RVpVdXJvS21jSnB6L3o1YWh5N08yUT09

I would like to request the faculty to forward these to their department
graduate students and postdocs.

A note to Biophysics students, this seminar counts towards the BPHY 252
seminar series.

Thank You!

Best regards,
Navaira Sherwani
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