<div dir="ltr"><p class="gmail-MsoTitle" style="margin:0in;text-align:center;font-size:22pt;font-family:Times,serif;font-weight:bold"><span style="font-size:16pt;font-family:Arial,sans-serif">CMDB281:  SEMINAR IN </span></p>

<p class="MsoNormal" align="center" style="text-align:center;margin:0in;font-size:12pt;font-family:Times,serif"><b><span style="font-size:16pt;font-family:Arial,sans-serif">MOLECULAR
CELL BIOLOGY</span></b></p>

<p class="MsoNormal" align="center" style="text-align:center;margin:0in;font-size:12pt;font-family:Times,serif"><b><span style="font-size:16pt;font-family:Arial,sans-serif">Spring 2025</span></b></p>

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<p class="MsoNormal" align="center" style="text-align:center;margin:0in;font-size:12pt;font-family:Times,serif"><b><u><span style="font-size:16pt;font-family:Arial,sans-serif;color:rgb(60,42,255)">Cell and Molecular Basis of </span></u></b></p>

<p class="MsoNormal" align="center" style="text-align:center;margin:0in;font-size:12pt;font-family:Times,serif"><b><u><span style="font-size:16pt;font-family:Arial,sans-serif;color:rgb(60,42,255)">Oxidative Stress-induced mitochondrial dysfunction, cell death
and inflammation </span></u></b></p>

<p class="MsoNormal" style="margin:0in;font-size:12pt;font-family:Times,serif"><b><u><span style="font-size:16pt;font-family:Arial,sans-serif"><span style="text-decoration-line:none"> </span></span></u></b></p>

<p class="MsoNormal" align="center" style="margin:0in 0in 0in 2.75in;text-align:center;font-size:12pt;font-family:Times,serif"><b><span style="font-size:16pt;font-family:Arial,sans-serif">Instructor: Dr. M.
Martins-Green</span></b></p>

<p class="MsoNormal" align="center" style="margin:0in 0in 0in 2.75in;text-align:center;font-size:12pt;font-family:Times,serif"><b><span style="font-size:16pt;font-family:Arial,sans-serif">Department of Molecular,
Cell and System Biology</span></b></p>

<p class="MsoNormal" align="center" style="text-align:center;margin:0in;font-size:12pt;font-family:Times,serif"><b><u><span style="font-family:Arial,sans-serif"><span style="text-decoration-line:none"> </span></span></u></b></p>

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<p class="MsoNormal" style="margin:0in;font-size:12pt;font-family:Times,serif"><span style="font-family:Arial,sans-serif">The
maintenance of biological redox potential <i>in
vivo</i> is vital for the proper function and integrity of cells, tissues,
organs and physiological systems. Recent evidence showing the destructive roles
of excess oxidative stress in mitochondrial function, cell death and inflammation
is mounting resulting in imbalanced redox causing diseases such as diabetes, atherosclerosis
and impaired/chronic wounds. In this class we will learn about the mechanisms
by which oxidative stress, mitochondrial dysfunction and inflammation play in
destroying the body at the cellular and molecular level leading to disease.
This class will help us look at disease in a different light, and see that in
most cases disease is caused by excess levels of oxidative stress. </span></p>

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<p class="MsoNormal" style="text-align:justify;margin:0in;font-size:12pt;font-family:Times,serif"><b><span style="font-family:Arial,sans-serif">Organizational meeting on Wednesday the 8th of
April at 12-1 pm in BSB 2101.  </span></b><span style="font-family:Arial,sans-serif">At this
meeting I will discuss the mechanics of the course and my expectations and will
answer any questions/concerns you might have. 
We will also discuss the best time for the class and potential subtopics
you can choose from the general topic for your presentation.   Alternatively, you can suggest your own
topic so long as it is within the subject of the course. </span></p>

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<p class="MsoNormal" style="text-align:justify;margin:0in;font-size:12pt;font-family:Times,serif"><b><span style="font-family:Arial,sans-serif">For questions: </span></b><span style="font-family:Arial,sans-serif">Dr.<b> </b>Martins-Green </span></p>

<p class="MsoNormal" style="text-align:justify;margin:0in;font-size:12pt;font-family:Times,serif"><span style="font-family:Arial,sans-serif">                         2117 Biological Sciences Building                                                                                   email: <a href="mailto:manuela.martins@ucr.edu">manuela.martins@ucr.edu</a> </span></p></div>